Table 1 Characteristics of all patients and hospital stays with sepsis, metropolitan France 2018-2022
| Â | 2018 | 2019 | 2020 | 2021 | 2022 |
|---|---|---|---|---|---|
(n=229,668) | (n=232,355) | (n=242,175) | (n=236,076) | (n=207,409) | |
Patient’s characteristics, n (%) | |||||
Sex | |||||
Male | 132,634 (57.8) | 134,393 (57.8) | 145,487 (60.1) | 142,733 (60.5) | 123,952 (59.8) |
Female | 97,034 (42.2) | 97,962 (42.2) | 96,688 (39.9) | 93,343 (39.5) | 83,457 (40.2) |
Age (years) | |||||
15-29 | 6,733 (2.9) | 6,660 (2.9) | 6,065 (2.5) | 6,025 (2.6) | 5,662 (2.7) |
30-44 | 12,655 (5.5) | 12,305 (5.3) | 12,692 (5.2) | 13,960 (5.9) | 11,101 (5.4) |
45-54 | 18,616 (8.1) | 18,403 (7.9) | 20,015 (8.3) | 21,023 (8.9) | 15,712 (7.6) |
55-64 | 37,405 (16.3) | 36,963 (15.9) | 40,274 (16.6) | 40,895 (17.3) | 32,942 (15.9) |
65-74 | 56,831 (24.8) | 58,653 (25.2) | 64,846 (26.8) | 65,275 (27.7) | 55,946 (27.0) |
75-84 | 55,169 (24.0) | 55,471 (23.9) | 56,757 (23.4) | 52,230 (22.1) | 49,863 (24.0) |
≥ 85 | 42,259 (18.4) | 43,900 (18.9) | 41,526 (17.2) | 36,668 (15.5) | 36,183 (17.4) |
Median [IQR] | 71 [60-82] | 72 [61-82] | 71 [61-81] | 70 [60-80] | 72 [61-81] |
Charlson index | |||||
0 | 78,016 (34.0) | 79,069 (34.0) | 87,971 (36.3) | 91,391 (38.7) | 68,824 (33.2) |
1-2 | 82,087 (35.7) | 83,294 (35.9) | 85,217 (35.2) | 80,231 (34.0) | 74,978 (36.2) |
3-4 | 34,185 (14.9) | 34,477 (14.8) | 34,569 (14.3) | 33,014 (14.0) | 33,201 (16.0) |
≥ 5 | 35,380 (15.4) | 35,515 (15.3) | 34,418 (14.2) | 31,440 (13.3) | 30,406 (14.7) |
Median [IQR] | 2 [0-3] | 2 [0-3] | 2 [0-3] | 2 [0-3] | 2 [0-3] |
Comorbidities | |||||
Cancer | 56,189 (24.5) | 56,302 (24.2) | 54,470 (22.5) | 49,184 (20.8) | 47,177 (22.8) |
Congestive heart failure | 49,777 (21.7) | 49,857 (21.5) | 50,224 (20.7) | 48,874 (20.7) | 48,883 (23.6) |
Renal disease | 30,599 (13.3) | 31,718 (13.7) | 32,619 (13.5) | 31,675 (13.4) | 31,341 (15.1) |
Chronic pulmonary disease | 27,097 (11.8) | 27,545 (11.9) | 28,358 (11.7) | 27,966 (11.9) | 28,206 (13.6) |
Metastatic carcinoma | 23,378 (10.2) | 23,676 (10.2) | 22,850 (9.4) | 20,340 (8.6) | 19,114 (9.2) |
Diabetes with chronic complications | 13,772 (6.0) | 13,825 (5.9) | 14,220 (5.9) | 13,270 (5.6) | 11,925 (5.8) |
Paraplegia or hemiplegia | 13,270 (5.8) | 13,311 (5.7) | 13,808 (5.7) | 13,343 (5.7) | 12,161 (5.9) |
Dementia | 11,865 (5.2) | 11,814 (5.1) | 11,305 (4.7) | 9,691 (4.1) | 9,570 (4.6) |
Mild liver disease | 12,426 (5.4) | 12,779 (5.5) | 13,010 (5.4) | 12,396 (5.3) | 11,863 (5.7) |
Moderate or severe liver disease | 5,900 (2.6) | 5,839 (2.5) | 5,757 (2.4) | 5,320 (2.3) | 5,494 (2.7) |
Rheumatological disease | 2,859 (1.2) | 2,943 (1.3) | 3,045 (1.3) | 2,983 (1.3) | 2,775 (1.3) |
AIDS | 1,113 (0.5) | 1,033 (0.4) | 1,028 (0.4) | 895 (0.4) | 830 (0.4) |
Infection sites | |||||
Multiple sites | 51,079 (22.2) | 51,718 (22.3) | 49,820 (20.6) | 46,671 (19.8) | 46,760 (22.5) |
Lower respiratory tract | 46,192 (20.1) | 45,727 (19.7) | 70,773 (29.2) | 82,166 (34.8) | 58,153 (28.0) |
Blood | 36,533 (15.9) | 36,634 (15.8) | 33,001 (13.6) | 29,611 (12.5) | 27,796 (13.4) |
Urinary and genital tract | 34,945 (15.2) | 35,904 (15.5) | 33,422 (13.8) | 28,972 (12.3) | 26,743 (12.9) |
Gastrointestinal and abdomen | 14,232 (6.2) | 14,516 (6.3) | 13,683 (5.7) | 12,296 (5.2) | 11,280 (5.4) |
Heart and mediastinum | 11,248 (4.9) | 11,546 (5.0) | 10,592 (4.4) | 8,803 (3.7) | 8,062 (3.9) |
Skin and soft tissues | 10,940 (4.8) | 11,205 (4.8) | 9,923 (4.1) | 9,010 (3.8) | 8,743 (4.2) |
Medical devices | 7,865 (3.4) | 7,909 (3.4) | 7,073 (2.9) | 6,171 (2.6) | 5,409 (2.6) |
Bones and joints | 4,716 (2.1) | 5,005 (2.2) | 4,401 (1.8) | 4,041 (1.7) | 3,925 (1.9) |
Nervous system | 897 (0.4) | 931 (0.4) | 652 (0.3) | 605 (0.3) | 713 (0.3) |
Ears, nose and throat | 364 (0.2) | 365 (0.2) | 244 (0.1) | 219 (0.1) | 223 (0.1) |
Pregnancy | 314 (0.1) | 314 (0.1) | 283 (0.1) | 269 (0.1) | 266 (0.1) |
Eyes | 34 (0.0) | 30 (0.0) | 24 (0.0) | 28 (0.0) | 23 (0.0) |
Unknown | 10,309 (4.5) | 10,551 (4.5) | 8,284 (3.4) | 7,214 (3.1) | 9,313 (4.5) |
Hospital stay’s characteristics, n (%) | |||||
Admission source | |||||
Home | 196,327 (85.5) | 198,541 (85.5) | 203,739 (84.2) | 195,690 (82.9) | 174,809 (84.3) |
Acute care | 28,229 (12.3) | 28,721 (12.3) | 33,501 (13.8) | 36,036 (15.3) | 28,638 (13.8) |
Long-term care | 5,112 (2.2) | 5,093 (2.2) | 4,935 (2.0) | 4,350 (1.8) | 3,962 (1.9) |
Length of stay (days) | |||||
<7 | 54,997 (24.0) | 56,279 (24.2) | 56,313 (23.3) | 53,128 (22.5) | 50,686 (24.4) |
7-14 | 70,992 (30.9) | 72,115 (31.0) | 76,096 (31.4) | 75,278 (31.9) | 62,778 (30.3) |
15-30 | 65,753 (28.6) | 66,128 (28.5) | 70,818 (29.2) | 68,004 (28.8) | 58,161 (28.0) |
>30 | 37,926 (16.5) | 37,833 (16.3) | 38,948 (16.1) | 39,666 (16.8) | 35,784 (17.3) |
Median [IQR] | 13 [7-24] | 13 [7-23] | 13 [7-23] | 13 [7-24] | 13 [7-24] |
ICU admissiona | |||||
Yes | 130,948 (57.0) | 130,540 (56.2) | 144,505 (59.7) | 149,986 (63.5) | 128,587 (62.0) |
No | 98,720 (43.0) | 101,815 (43.8) | 97,670 (40.3) | 86,090 (36.5) | 78,822 (38.0) |
Septic shocka | |||||
Yes | 52,690 (22.9) | 53,328 (23.0) | 52,467 (21.7) | 49,579 (21.0) | 49,365 (23.8) |
No | 176,978 (77.1) | 179,027 (77.0) | 189,708 (78.3) | 186.497 (79.0) | 158,044 (76.2) |
Hospital discharge | |||||
Home | 111,786 (48.7) | 114,054 (49.1) | 116,081 (47.9) | 111,303 (47.2) | 96,273 (46.4) |
Acute care | 27,746 (12.1) | 27,267 (11.7) | 26,633 (11.0) | 25,900 (11.0) | 22,818 (11.0) |
Long-term care | 35,903 (15.6) | 36,625 (15.8) | 39,583 (16.3) | 37,252 (15.8) | 31,115 (15.0) |
Death | 54,233 (23.6) | 54,409 (23.4) | 59,878 (24.7) | 61,621 (26.1) | 57,203 (27.6) |