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Table 1 Demographics and clinical characteristics of population at baseline

From: Influence of anti-Spike protein antibody levels on tocilizumab efficacy in hospitalized patients with severe COVID-19 pneumonia: a post-hoc analysis of the COVACTA trial

 

Tocilizumab

Placebo

Male sex, n (%)

205 (69.7)

101 (70.1)

Age [yr], Median (P25, P75)

62 (51, 70)

61 (53.5, 70)

Mechanical Ventilation at baseline = Yes, n (%)

110 (37.4)

55 (38.2)

Extracorporeal membrane oxygenation (ECMO) at baseline = Yes, n (%)

10 (3.4)

8 (5.6)

Intensive Care Unit (ICU) Stay at baseline = Yes, n (%)

167 (56.8)

80 (55.6)

Days from first COVID-19 symptom at baseline, Median (P25, P75)

11 (7.5, 15)

10 (7, 14)

Antiviral Treatment at baseline = Yes, n (%)

71 (24.1)

42 (29.2)

Coexisting illness, n (%)

  

≥ 1 Diagnosis

231 (78.6)

124 (86.1)

Obesity

63 (21.4)

27 (18.8)

Diabetes

105 (35.7)

62 (43.1)

Cardiovascular impairment

88 (29.9)

35 (24.3)

Hypertension

178 (60.5)

94 (65.3)

Hepatic impairment

6 (2.0)

2 (1.4)

Chronic lung disease

49 (16.7)

22 (15.3)

  1. Antiviral treatment corresponds to treatment with remdesivir, which was the only available treatment at that time. The coexisting illnesses are sourced from the COVACTA clinical trial article [4]