Risk stratification and conservative management of women aged 25–40 years with cervical intraepithelial neoplasia grade 2(CIN2)

Table 2 Age ≥ 25 years old, cytological data and HPV data of patients according to the status of cone histopathology

Classification	Total (N)	Cone histopathology		P value
Classification	Total (N)	≤ CIN2	≥ CIN3	P value
Age (years)	307			0.01^*
< 25 years old	42	39(92.9%)	3 (7.1%)
≥ 25 years old	265	199 (75.1%)	66(24.9%)
Cytology	265			< 0.001^*
≤ LSIL^†	220	175 (79.5%)	45 (20.5%)
HSIL^‡	45	24(53.3%)	21 (46.7%)
HPV genotype	265			0.02^*
HPV16/18	127	87 (68.5%)	40(31.5%)
Other HR-HPV	138	112(81.2%)	26 (18.8%)
The number of HPV subtype	265			0.08
One HPV subtype	173	124 (71.7%)	49 (28.3%)
Two HPV subtypes or more	92	75(81.5%)	17 (18.5%)
HPV16 or 18 co-infection with another high-risk HPV	127			0.56
Yes	48	34(70.8%)	14(29.2%)
No	79	52(65.8%)	27(34.2%)

^*p < 0.05. ^†including NILM, ASC-US and LSIL; ^‡including ASC-H and HSIL. NILM: negative for intraepithelial lesion or malignancy; ASC-US: atypical squamous cells of undetermined significance; LSIL: low-grade squamous intraepithelial lesion; ASC-H: atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion; HSIL: high-grade squamous intraepithelial lesion; HR-HPV: high-risk human papillomavirus

ISSN: 1471-2334